NEUROENDOCRINE-IMMUNE AND METABOLIC ACCOMPANIMENTS OF CHOLECYSTOKINETIC EFFECTS OF BALNEOTHERAPY ON SPA TRUSKAVETS’
MARFIYAN O. M.
JSC “Truskavets’ kurort”, Truskavets, Ukraine
OO Bohomolets’ National Medical University, Kyiv, Ukraine
Objective. Ability balneofactors spa Truskavets’ (Ukraine), including bioactive water Naftussya, affect Gall-bladder motility has long been known. We set a goal to identify changes related neuroendocrine-immune complex and metabolism accompanying cholecystokinetic effect of balneotherapy on spa.
Results. In observation of 22 men with chronic cholecystitis in combination with pyelonephritis, found that 10-12-day course of balneotherapy (drinking of bioactive water Naftussya, application of ozokerite, mineral baths) reduces Gall-bladder volume fasting by 16% (p< 0,001) and increases its contractile response to 40% solution of xylitol by 44% (p<0,001). This is accompanied by noticeable modulation of neuroendocrine-immune complex. In particular, decreases as the absolute and relative power spectral density (PSD) θ- and α-rhythms (p<0,05÷0,01) and increased relative PSD β-rhythm (p<0,05÷0,02) ongoing EEG. However, reduced heart rate variability indices: (VLF+LF)/HF by 34% (p<0,05) and LF/HF by 32% (p>0,05), by increasing PSD HF greater extent than LF. The basal levels of plasma cortisol decreased by 20% (p<0,01), testosterone by 15% (p=0,01), whereas increased levels of triiodothyronine (by 4%, p<0,05) and especially of calcitonin activity (92%, p<0,001)), calculated by urinary excretion of phosphates and calcium, which increases according by 103% (p<0,001) and 76% (p<0,01). It notes that higher urinary excretion of oxalates by 52% (p<0,001), creatinine by 32% (p<0,02), uric acid by 29% (p<0,001), urea by 21% (p<0,01), magnesium by 19% (p=0,05), with no significant changes in urinary excretion of chloride, potassium and sodium. This reduces the plasma level of creatinine by 14% (p<0,001) and urea by 11% (p<0,01). With respect to the parameters neutrophil phagocytic function stated increasing of index killing them Staphylococcus aureus by 19% (p<0,001) and Escherichia coli by 18% (p<0,01), coupled with a decrease in the number of microbes absorbed one phagocyte by 4% (p>0,2) and 8% (p<0,05) respectively. Regarding immunity parameters revealed significant increase in blood CD16+ lymphocytes only (+17%, p<0,01) in the absence of changes in levels of CD3+CD4+ and CD3+CD8+ T cells and CD19+ B lymphocytes. Do not change significantly either serum Igg G, M, A, or circulating immune complexes. Finally, stated a slight but significant increase electrokinetic index cell nuclei of buccal epithelium, indicating the "rejuvenation" of the body.
Conclusion: balneotherapy on spa Truskavets’ be significantly cholecystokinetic effect, combined with the activation excretory and depurative kidney functions and neutrophil bactericidal function against a background of lower levels of neuroendocrine markers of stress.