RELATIONSHIPS BETWEEN PARAMETERS OF GALL-BLADDER MOTILITY AND NEUROENDOCRINE-IMMUNE COMPLEX AND METABOLISM IN MEN WITH CHRONIC CHOLECYSTITIS AND PYELONEPHRITIS
MARFIYAN O. M.
JSC “Truskavets’ kurort”, Truskavets, Ukraine
OO Bohomolets’ National Medical University, Kyiv, Ukraine
Objective. Long known about cholecystokinetic and diuretic effects balneotherapy on spa Truskavets’. However known about modulation by bioactive water Naftussya neuroendocrine-immune complex.
Aim: clarification relationships between parameters of gall-bladder motility and neuroendocrine-immune complex as well as metabolism.
Material and Methods. At 22 men with chronic cholecystitis combined with pyelonephritis we recorded basal and postprandial volume of gall-bladder (Echoscopy by “Radmir”), urinary excretion electrolytes and nitrogenous metabolites, EEG ("NeuroCom"), HRV ("CardioLab+HRV"), plasma level of cortisol, testosterone and triiodthyronine (ELISA), routine immune parameters.
Results. Discovered 23 neural, metabolic and immune parameters, canonical correlation which with the parameters of gall-bladder motility is very strong. In particular, basal and early (in 5 min) postprandial volume determinated positively by HRV markers of vagal tone (pNN50, HF, LF, VLF), Bayevskiy’s activity regulatory systems index, α-rhythm laterality index, θ-rhythm deviation, circulating immune complexes, chloride and magnesium urina concentration and electrokinetic index buccal epithelium as marker of biological age, while negatively determinated by passport age as well as by α-rhythm frequency, oxaluria and body massa. Tardy (in 15 and 30 min) postprandial volume determinated negatively by θ-rhythm asymmetry, killing index by neutrophils Staphylococcus aureus, glomerular filtration, diurese, creatinineuria, phosphaturia, while positively by sodium urina concentration.
Conclusion. Cholecystokinetic effect balneotherapy on spa Truskavets’ may be the result of modulation of neuroendocrine-immune complex.